What Is the Dapoxetine Drug?
Created in the labs of Eli Lilly and Company, it was considered to be useless for a long time before its curative virtues were discovered. In 2004, dapoxetine was submitted to the US Food and Drugs Administration as the natural remedy for premature ejaculation. It was the first pharmacological treatment for PE. In our days, dapoxetine belonged to Johnson and Johnson, and it is marketed in some European and Asian countries, Latin America, and New Zealand under different trade names:
- Priligy — the most popular brand approved and distributed by different companies in Eastern Europe, Great Britain, Ireland, Portugal, Switzerland, Spain, Finland, France, Italy, Germany and other European countries, South Korea, Singapore, Malaysia, Thailand, Hong Kong, New Zealand and Mexico;
- Dasutra, Kutub, Xydap, Sustinex, Duratia are the not full list of trade names of dapoxetine tablets produced and commercialized in India;
- Lejam is the drug manufactured in Saudi Arabia and Joypox — in Egypt;
- Prolongal, Lagose, Precoce and Extensil are Argentinian medicines;
- and other trademarks and generic names, such as Westoxetin, Pentenal-30, Dapoxetine Hydrochloride etc.
In our online pharmacy, we offer pills of the highest effectiveness and fairest price. There are combo trial packsavailable, where everyone can order from 100 to 1000 tablets in any combination of the most popular drugs, such as Viagra, Cialis, Female Viagra, and Priligy 60 mg. This is the best offer to try medicines and choose the most efficacious for beneficial price and with free shipping.
According to American standards, there are four phases for the clinical trials of drugs. When the new medicine passes the first three of them, it usually gets the approval of the medical authorities for use in the country. This process of development of the drugs takes many years. Phase IV is the studies that take place after the drug is certified for marketing.
Dapoxetine is in the third phase trials since 2003. It was applied for approval by the FDA in 2004 as dapoxetine hydrochloride, but in 2005, it was rejected. There were two more testings conducted in 2006 and new applications to FDA, but American administration has certain concerns about the side effects. There is a hope, though, that soon dapoxetine will be approved for production and marketing in the USA.
Anyway, any American user can acquire this remedy in India, Europe, Egypt, or Mexico. CialisBit suggests the easiest decision for this issue, as anyone can get the necessary medication online from the world-famous producers completely legally with the guarantee of high quality and safety.
Forms and Dosages
All listed above dapoxetine drugs are manufactured in the form of firm-coated tablets with different active ingredient contents. Tablets that contain pure dapoxetine have 30, 60, and 90 mg of it and are sold in packages from 20 to 500 tabs. Dapoxetine hydrochloride exists in liquid form, as it is sold only for research purposes and cannot be used as treatment for humans.
There are also pills that combine medications for erectile and ejaculation maladies:
- Tadapox is the brand name of the combination of 60 mg of dapoxetine and tadalafil 20 mg;
- Super P-Force, or Super Viagra, and Sildigra Super Power are the brands of pills with 100 or 50 mg of sildenafil and dapoxetine 60 or 30 mg available for sale;
- vardenafil and dapoxetine are the components or Super Zhewitra, Super Levitra, Super Valetra, Snovitra Super Power and others.
The optimal measuring for a single use is 60 mg, but the patient can change it depending on the response of the organism to the initial dose.
Who Can Use Dapoxetine HCL?
Dapoxetine hydrochloride is the SSRI inhibitor, and one of the properties of this medicament is its quick operation and quick elimination in the blood. This quality makes it the best for pharmacological treatment of PE. Who needs it? Obviously, men with rapid ejaculation observed on regular or constant basis.
The average man’s ejaculatory time is 4-8 minutes after penetration. This parameter varies from man to man and from sexual act to sexual act, but there is the common opinion in medical science that the term premature should be used in cases when men have orgasm and emits semen as soon after the beginning of sexual intercourse as one minute or less. The International Classification of Diseases has the concrete indicator of 15 seconds. Sometimes the rapid semen emission comes even before the penetration.
How and When to Take Dapoxetine Pills?
As the causes of PE are not clearly determined yet, and there can be many reasons for it, the decision if there is a need to take medication must be done carefully but without procrastination. One time rapid orgasm can be explained by extra excitement or sexual abstinence for too long. But regular or constant troubles with the normal accomplishment of coitus requires medical advice and proper treatment.
It is recommended to read prescribing information carefully to learn how to take the pills. If the PE is not caused by prostatitis or the side effect of some medication, dapoxetine can cure this dysfunction. The starting average dosage is 30 mg taken from one to three hours before sex. Dapoxetine HCL should be administered on daily basis to achieve the stable and long effect. There are rigorous restrictions for dapoxetine usage:
- one tablet in 24 hours;
- allowed for men between 18 and 64 years old;
- recommended to take only if the regular PE is noticed not less than six months.
Clinical research with double blinds and randomized selection with placebo control showed that 60 mg gave better results than 30 mg among men who have lifelong rapid orgasming, but men with aquired illness did not feel any difference.
Can I Take Dapoxetine and Sildenafil Together?
In some cases, men can have premature ejaculation accompanied with ED. In such cases two different substances should be used. Viagra and Priligy can work together very effectively with some precautions. Both medications can cause low blood pressure, so men with BP problems have to take this combination carefully. Only your doctor or pharmacist can give you professional advice on how to use the medications with no harm to your health.
At the same time, the two drugs have similar side effects and contraindications, systems of administration, working on different problems, and influencing the different areas or neural system. That makes these drugs highly combinable, and together they occur to be a very effective remedy for those who have problems with both erection and ejaculation. Thus, the answer for the question “can dapoxetine and sildenafil be taken together” is yes!
Is Dapoxetine Used for Depression?
Dapoxetine HCL was originally developed to treat depression, but never used as an antidepressant. Being the homogeneous preparation with such pharmacologic agents as fluoxetine, sertraline, paroxetine, and other selective serotonin reuptake inhibitors, it has the different, shorter working time, and due to this aspect it does not affect depression properly.
Is It Safe?
Phase I and III trials of dapoxetine for safety showed that it has no harmful impact to men’s cardiovascular systems. No electrocardiographic abnormalities were detected in patients who took the drug.
In 2012, there were studies conducted to reveal the negative effect of dapoxetine on mood and psychiatric stability. There was no connection disclosed between the usage of this drug and anxiety and suicidal thoughts. Dapoxetine does not cause addiction or withdrawal symptoms.
How Does Dapoxetine Work?
Dapoxetine blocks the reuptake of serotonin by neurons that result in the increase of it in the synaptic cleft. High concentration of serotonin in neural system provides a better communication between brain cells. As any process in an organism, ejaculation depends on CNS, and proper messaging in nerves helps to control the length of sexual act. Another effect of dapoxetine is the temporary lowering of disturbance and frustration and mood normalization, which also positively influences sexual health, including the ejaculatory time.
How Long Does It Stay in Your System?
After oral administration, dapoxetine reaches its steady-state concentration in the blood in 1-2 hours. It is metabolized by the liver, and the time of excretion with the urine is 19 hours for 30 mg to 22 hours for 60 mg.
Dapoxetine Side Effects
Taking dapoxetine medicines may cause some adverse effects, the most noticed of which are:
- dizziness, especially when standing up quickly. In this case it is recommended to sit or lay down till the discomfort feeling passes;
- fainting, sickness — also better lay down for some time not to fall and get hurt;
- headache, nausea, diarrhea have to be treated symptomatically;
- dry mouth, insomnia, common cold.
Usually these undesired consequences do not last for long and are mild. If they are observed for a long period of time and get severe, it is better to stop drug administration and get the instructions from doctor.
There are certain contraindications for dapoxetine usage. It is forbidden for men with cardiostimulator, ischemic disease, heart failure, liver or kidney decompensation, glaucoma, and epilepsy. It is better to ask for professional medical advice if you have any chronic diseases or take any medications.
Interaction of Dapoxetine
As all drugs, dapoxetine can change its action depending on how and when it was taken, and with whatever other drugs it is taken with.
Can I Use Dapoxetine with Food?
Dapoxetine can be used with and without food, and it is recommended to take it with enough water. Fat food can reduce the maximum plasma concentration of the substance, but only insignificantly.
Studies did not display the effect of alcohol on dapoxetine action, though it is recommended to use alcoholic beverages in reasonable measures, as they can raise the risk of such side effects as dizziness, confusion, and fainting.
Taking the serotonin transporter inhibitor with other drugs can either reduce or increase its effectiveness, or result in harmful or undesired consequences. Be careful and ask for professional consultation if you take dapoxetine with:
- other SSRIs, monoamine oxidase inhibitors and tricyclic antidepressants;
- antimycotics and macrolide antibiotics;
- antiretroviral therapy;
- nitrates and alpha-blockers;
- tramadol and others.
Do not use dapoxetine earlier than two weeks after the last intake of any antidepressants.
This medication was the first pharmacological remedy for premature ejaculation, and it remains the best and really efficacious treatment for men with this problem. No preparation gives the same effect as quickly as the first intake.
Dapoxetine Vs Cialis (Tadalafil)
Dapoxetine and tadalafil cure different dysfunctions and cannot substitute for one another in any manner. But they can work in tandem to help men who have ED plus PE contemporary.
As well as Cialis, Viagra is not the counterpart for Priligy and congeners but is a good remedy for erectile dysfunction. The combination of sildenafil and dapoxetine is one of the most popular treatments for both sexual disorders.
Dapoxetine Vs Paroxetine
Paroxetine has the same mechanism of action, but it is used to treat depression. Comparing dapoxetine vs paroxetine, we should consider two sides of this matching:
- how dapoxetine works as antidepressant;
- and how paroxetine works as the remedy for PE.
Dapoxetine never worked for depression treatment as it does not stay in the blood for enough time. The half-life of this drug is several hours and with one time a day schedule, it is not effective in this matter.
As there is no certified drug for premature ejaculation in the USA, paroxetine has been prescribed to cure it. But the further research shows that it stays in the blood for too long, and daily administrations lead to accumulation and to such side effects as the loss of sexual desire, impotence, and others.
Fluoxetine Versus Dapoxetine
The comparison of dapoxetine vs fluoxetine will be the same as the one vs paroxetine. Fluoxetine is an antidepressant and works only for this purpose. It was attempted to be used to help with PE, but it showed adverse effects.
Dapoxetine Reviews & User’s Experience
Our online pharmacy receives dozens of comments and positive responses from customers. Their experiences using Priligy 60 mg and other dapoxetine-containing pills are all stories with happy endings. Read them and see how this innovative medication helps men all over the world who did not know how to get healthy and harmonious sexual lives before they found us.
Where to Buy Dapoxetine Online?
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How Can I Get Dapoxetine Without Prescription?
As in the USA and many other countries, Priligy and dapoxetine generics are not licensed, and many men ask themselves “where can I buy it without prescription”. We provide them with this possibility, along with anonymity and safety, fast shipping, and various discounts and special offers. For example, shipping is free if your order exceeds 150 dollars, and if you pay with bitcoins you get 35% discount. And the fair cost is not a sign of quality loss, as we offer reliable, safe, and efficient dapoxetine tablets, Priligy, and its alternatives.